Ukrainian adaptation of the nomenclature of the International Consensus on Antinuclear Antibody Patterns

Видання

Вісник Харківського національного університету імені В. Н. Каразіна. Серія «Медицина»

Анотація

<jats:p>Background. Diagnosis of autoimmune diseases remains a complex multi-stage process that includes various methods of laboratory testing. The gold standard for serological diagnosis of autoimmune connective tissue disorders is the indirect immunofluorescence assay (IFA) on HEp-2 cells. The result of the test is a description of the morphological pattern observed in the assay, which correlates with the corresponding autoantibodies and allows to direct further diagnostics. The most recent and most comprehensive attempt to describe HEp-2 IFA patterns was made by the International Consensus on Antinuclear Antibody (ANA) Patterns (ICAP).

Purpose. Ukrainian adaptation of the ICAP nomenclature was developed to provide for seamless harmonization and integration with international protocols.

Materials and methods. Ukrainian adaptation was based on the materials the International Consensus on Antinuclear Antibody (ANA) Patterns (ICAP).

Results. Ukrainian nomenclature of HEp-2 IFA patterns is provided in accordance with ICAP nomenclature, to be used a tool for comprehensive description of HEp-2 IFA results and guidance for clinicians

Conclusions. With the introduction and universal use of the Ukrainian adaptation of ICAP nomenclature, the laboratory diagnosis of autoimmune connective tissue diseases is approaching international standards, which creates conditions for the integration of international protocols for the diagnosis and treatment of these pathologies.</jats:p>

Автори

Тарасов Є. В.; Kurtova M.; Кольцова І. Г.; Шевчук Г.; Грузевський О. А.